Three presentations
- Triple assessment makes the diagnosis: clinical examination, imaging (ultrasound under 40, mammography and ultrasound over 40), and a core biopsy of anything solid or suspicious. A normal examination alone does not exclude cancer.
- Inflammatory signs in a non-lactating breast that do not settle with a course of antibiotics are inflammatory cancer until biopsied.
| Presentation | Usually | Refer when |
|---|---|---|
| A lump | Fibroadenoma in the young, cyst in the 30s to 50s, fibrocystic change | Any discrete new lump, a lump persisting after a period, a lump over 30, skin or nipple change, an axillary node |
| Pain | Cyclical mastalgia (bilateral, premenstrual, resolves); non-cyclical from the chest wall | Focal persistent pain with a mass or in a postmenopausal woman |
| Nipple discharge | Physiological (bilateral, multiduct, on expression), duct ectasia, prolactinoma if milky and bilateral (check prolactin, medicines) | Spontaneous, single-duct, bloody or clear, or with a mass: papilloma or, less often, cancer |
Screening and risk
- Average risk: screening mammography every 2 to 3 years from 50 to 74 in Canadian Task Force guidance, with shared decision-making from 40 and where provincial programmes now start at 40; other countries differ, so name the programme you practise in.
- Breast self-examination and routine clinical breast examination are not recommended as screening in average-risk women; breast awareness (knowing what is normal for her and reporting change) is.
- High risk: a known BRCA1 or BRCA2 or other pathogenic variant, a first-degree relative with a variant, prior chest radiotherapy before 30, or a calculated lifetime risk of 25 percent or more: annual MRI with mammography from 25 to 30, genetics referral, and a conversation about risk-reducing options.
- Refer to genetics for: breast cancer under 50 in a first-degree relative, two or more relatives on one side, male breast cancer, ovarian cancer, Ashkenazi Jewish ancestry with breast or ovarian cancer, or a known family variant.
- Density: dense breasts lower the sensitivity of mammography and raise risk modestly; supplemental imaging is by programme and shared decision.
Check
A 27-year-old has a smooth, mobile, painless 2 cm lump she noticed a month ago. What next?