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Vaginal discharge, vaginitis and pelvic inflammatory disease

Gynaecology

Three common causes of discharge with three different treatments, and the infection above the cervix that scars the tubes.

The three common vaginal causes

  • Physiological discharge changes through the cycle and in pregnancy; reassurance after excluding the three is a diagnosis too.
  • Cervicitis (chlamydia, gonorrhoea) is tested by NAAT on a vaginal or cervical swab or urine; contact tracing and retesting after treatment.
CauseDischargepHMicroscopyTreatment
Bacterial vaginosisThin, grey, fishy (positive whiff test)Over 4.5Clue cellsMetronidazole oral or vaginal, or clindamycin; not an STI but recurs
CandidaThick, white, itchy, with erythemaNormal (4 to 4.5)Hyphae and sporesTopical azole or oral fluconazole (topical in pregnancy)
TrichomonasFrothy, yellow-green, malodorous, cervicitisOver 4.5Motile trichomonads (NAAT is more sensitive)Metronidazole; treat partners; an STI

Pelvic inflammatory disease

  • Ascending infection: chlamydia, gonorrhoea, Mycoplasma genitalium and anaerobes. Lower abdominal pain, discharge, fever, dyspareunia, intermenstrual bleeding.
  • Diagnosis is clinical: cervical motion, uterine or adnexal tenderness in a sexually active woman with no other cause. The threshold to treat is deliberately low because the cost of missed disease is tubal infertility, ectopic pregnancy and chronic pain.
  • Outpatient: ceftriaxone intramuscularly plus doxycycline and metronidazole for 14 days. Admit for severe illness, a tubo-ovarian abscess, pregnancy, inability to take oral treatment, or failure to improve within 72 hours.
  • Tubo-ovarian abscess: intravenous antibiotics; drainage for large abscesses or failure to respond; rupture is a surgical emergency.
  • Treat partners, retest, and remove an IUD only if there is no improvement after 48 to 72 hours.

Left hydrosalpinx

Transvaginal, left adnexa. An elongated, tubular, fluid-filled structure with incomplete septa (the folded tube).

Open in the Ultrasound Lab

On the modelVaginaCervixFallopian tubes

Frameworks and sources

  • Cunningham et al.: Williams Obstetrics, 26th edition (maternal physiology, labour mechanics, placental anatomy) (2022).

Content reviewed 2026-09. Teaching material for students, not clinical decision support; check the current edition of the guideline your unit uses.